Micrological assessment of food supplements

Basically, in the EU we have the COMMISSION REGULATION (EC) No. 2073/2005 of 15 November 2005 on microbiological criteria for foodstuffs for the microbiological assessment of foodstuffs. (REG_2073/2005)

In addition, there are the microbiological guideline and warning values of the German Society for Hygiene and Microbiology (DGHM) e.V., which can be used as a recommendation. 

USP 2023 also recommends microbiological limit requirements for non-sterile dietary supplements. 

Recommended limits for herbal ingredients & products
Dried or powdered botanicals

Total aerobic plate count 10^5 CFU*/g or ml.
Total number of yeasts and molds 10^3 CFU*/g or ml. 
Galletolerant, Gram-negative bacteria 10^3 CFU*/g or ml. 
Absence of Salmonella spp. and E-coli in 10g. 

Powdered plant extracts

Total aerobic plate count 10^4 CFU*/g or ml.
Total number of yeasts and molds 10^3 CFU*/g or ml.
Absence of Salmonella spp. and E-coli in 10g.

Food supplement with botanicals

Total aerobic plate count 10^4 CFU*/g or ml.
Total number of yeasts and molds 10^3 CFU*/g or ml.
Absence of Salmonella spp. and E-coli in 10g. 

Recommended limits for dietary supplement ingredients & products 
Other raw material and dietary supplement ingredients & dietary supplements with synthetic or highly refined ingredients.

Total aerobic plate count 10^4 CFU*/g or ml. 
Total number of yeasts and molds 10^3 CFU*/g or ml.
Absence of Salmonella spp. and E-coli in 10g. 

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